Abstract Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However. pharmacological induction of hypothermia in most mammals remains a huge challenge. Here we show that a natural product P57 promptly induces hypothermia and decreases energy expenditure in mice. https://www.jmannino.com/save-now-3D-Key-Ring-Rainbow-Lorikeet-Pete-Cromer-Wilmot-Harvey-super-grab/